Dosing & Uses
AdultPediatric
Dosage Forms & Strengths
neomycin/polymyxin B/bacitracin ophthalmic
ophthalmic ointment
- 400 units/3.5mg/10,000 units/g
Ocular Inflammation/Infection
Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections
Dosage Forms & Strengths
neomycin/polymyxin B/bacitracin ophthalmic
ophthalmic ointment
- 400 units/3.5mg/10,000 units/g
Ocular Inflammation/Infection
Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections
Adverse Effects
Frequency Not Defined
Conjunctival edema
Rash
Allergic contact dermatitis
Itching
Failure to heal
Swelling
Irritation
Warnings
Contraindications
Hypersensivity to neomycin, polymyxin B, zinc bacitracin
Glaucoma
Viral diseases of cornea and conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella)
Mycobacterial infection of eye & fungal diseases of ocular structures
Cautions
Contamination of container may occur, causing bacterial keratitis; avoid contamination of product
Pregnancy & Lactation
Pregnancy Category: C
Lacation: Excretion in breast milk unknown; caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology
Mechanism of Action
Bacitracin: Inhibits bacterial cell wall synthesis by preventing the incorporation of amino acids and nucleotides into the cell wall
Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits
Polymyxin B: Bactericidal; causes leakage of bacterial membrane
Images
No images available for this drug.
Patient Handout
A Patient Handout is not currently available for this monograph.
Formulary
FormularyPatient Discounts
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
View explanations for tiers and restrictions
| 1 | This drug is available at the lowest co-pay. Most commonly, these are generic drugs. |
| 2 | This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. |
| 3 | This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. |
| 4 | This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. |
| 5 | This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. |
| 6 | This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. |
| NC | NOT COVERED – Drugs that are not covered by the plan. |
| PA | Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. |
| QL | Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. |
| ST | Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. |
| OR | Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. |
Non-Medicare Plans Medicare Plans
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.